He has worked with artists such as Aesop Rock, El-P, DJ Mr. Len, Breeze Brewin, Travis McCoy, Vast Aire, Yak Ballz, Hussein Fatal, Mos Def, Dro Pesci, etc.

[1] He joined the underground supergroup the Weathermen which was formed in 2002 by Cage and El-P, and the same year he released his first solo album and EC debut named When Rappers Attack.

Credited with making hip-hop's first song about "Molly" (MDMA, the active ingredient in Ecstasy) at this time, Tame met Staten Island rapper Dro Pesci.

In 2024, production duo Parallel Thought posthumously produced Acid Tab Vocab, "'Old Jersey Bastard'", and with Xing and Fox Spazmatic.

[6][7] Rahem's mother Darlene Harris utilizes Instagram and Facebook accounts to continue Tame One's artistic legacy.