The film also stars Susan Sarandon, Allison Janney, Gary Cole, Mark Duplass, Nat Faxon, Toni Collette, Sandra Oh, with Dan Aykroyd, and Kathy Bates.

The film tells the story of a woman named Tammy who hits the road with her profane, alcoholic grandmother after finding out her husband is cheating.

In Murphysboro, Illinois, Tammy Banks strikes a deer on the way to her job at the fast food restaurant Topper Jack's, where she is later dismissed for her frequent tardiness.

She tells her mother, Deb, about her plans to leave and takes her grandmother Pearl's Cadillac DeVille.

Tammy and Bobby begin a romantic relationship as Pearl and Earl drunkenly make out in the car.

To bail out Pearl, Tammy robs a local Topper Jack's, where she converses with employees Becky and Larry.

At a 4th of July party, a drunken Pearl humiliates Tammy by making rude comments about her weight and appearance in front of all the guests.

On November 17, 2011, was reported that New Line Cinema acquired Melissa McCarthy's script Tammy, about an overweight woman who is laid off from her job, discovers her husband is having an affair, and decides to go on a road trip with her alcoholic, foul-mouthed, diabetic grandmother.

[8] On October 18, 2012, it was announced that Shirley MacLaine had been offered the role of Tammy's diabetic grandmother, but the deal never came to fruition due to her scheduling conflicts with the TV series Downton Abbey.

The site's critical consensus reads, "Melissa McCarthy remains an engaging screen presence, but her efforts aren't enough to keep the jumbled Tammy on track.

[23] Ian Buckwalter of NPR gave the film a mixed review saying "Tammy never quite manages to find that balance between the sweet and the smartass the way Bridesmaids did, nor does the mismatched buddy dynamic between McCarthy and Sarandon ever approach the success of The Heat.

But eventually the film does manage to find its own awkward way, with enough effective and less desperate jokes to smooth things over after the rocky start.

It's a shakier debut of McCarthy and Falcone's efforts behind the camera than one might have hoped for, but if Tammy can turn things around, surely they can too.