On 29 May 2022, the Twin Otter aircraft carrying 22 people (19 passengers and 3 crew members) departed at 09:55 NPT (04:10 UTC) and lost contact with air traffic controllers about 12 minutes later at 10:07 (04:22).

In the cockpit voice recorder, it was observed that someone, either ground staff or some intimate passenger to the crew, advised strongly to the pilot to conduct the flight.

[10](p34) According to the Civil Aviation Authority of Nepal (CAAN), it lost contact with air traffic controllers at 10:07 am, above Ghorepani, Myagdi District.

[6] The phone location of the captain was tracked by search and rescue personnel with the assistance of Nepal Telecom.

A spokesperson from Yeti Airlines said that the tracking data indicated the phone's last location was around the vicinity of Lete, a village in the Mustang District.

[17] Air traffic controllers at Jomsom Airport also reported hearing a loud noise at around the time of the disappearance.

[18] Five[clarification needed] hours after it was reported missing, the wreckage of the plane was found near Kowang,[16] a village in the Mustang District.

[19] A Nepali Army brigadier general tweeted that the "loss of daylight and adverse weather" led to search and rescue being called off.

[20] On 30 May, about 20[clarification needed] hours after it was reported missing, the wreckage of the aircraft was located by local farmers in Sanosware, Thasang Rural Municipality in the Mustang District.

[10](p62) The recorded data showed the 'TAWS INHIBIT' feature had been selected by the flight crew for entire recorded flight due to which predictive Forward Looking Terrain Alert (FLTA), Imminent Terrain Impact (ITI), and Premature Descent Alert (PDA) were disabled.

Only Ground Proximity Warning System (GPWS) Alerts were active which was annunciated approximately 3 seconds just before the impact.

The senior pilot had taken almost all total flight related duties including flying, monitoring and communications.

The copilot failed to effectively monitor and challenge the senior pilot's decision which was causal to the accident.

The pilot in command was overloaded by all the cockpit duties while dealing with the unexpected weather which significantly degraded his performance and contributed to his failure to make proper decision while tackling the abnormal situation.