He has also appeared in other television series such as Wild 'n Out, The Amanda Show, How I Met Your Mother, New Girl, and in the main cast of Single Parents.

After MADtv, Killam appeared on TV shows such as Jake in Progress, Still Standing, Boston Public, Drake & Josh, Do Over, Roswell and Judging Amy.

[9] On November 10, 2012, Killam appeared with Kenan Thompson and Anne Hathaway in a SNL music video, "The Legend of Mokiki and the Sloppy Swish".

Mokiki is a laboratory test subject who wanders Manhattan performing a shuffling dance move known as the "Sloppy Swish".

[10][11] Mike Ryan of The Huffington Post wrote, "It is one of the most bizarre things to ever air on SNL, yet, the next day, everyone was talking about the Sloppy Swish.

[15] In 2011, Killam appeared in Community episode "Regional Holiday Music" as Mr. Radison (Mr. Rad), a parody of Will Schuester from Glee.

The series focuses on a team of illegitimate siblings who are charged with taking the place of their father, Jack Steele, a James Bond-like spy, after his death.

[16][17][18][19] Killam appears in the 2013 film 12 Years a Slave, playing the role of Abram Hamilton, one of the kidnappers who brings the main character into slavery.

[6] Killam made six guest appearances as Gary Blauman on his wife Cobie Smulders' TV series, How I Met Your Mother.

In 2015, Killam provided the voice of the titular character on the PBS Kids show Nature Cat, along with SNL alumni Kate McKinnon, Bobby Moynihan, and Kenan Thompson.

[citation needed] On January 17, 2017, Killam succeeded Rory O'Malley in the role of King George III in the Broadway musical Hamilton.

[20] Killam produced, scripted, directed and starred in the comic hitman film Killing Gunther, given a general release in fall 2017.

In March 2018, Killam was cast as a lead in the comedy pilot Single Parents[21] for ABC, which was picked up to series for a premiere on September 26 of that year.