He would move to Florence, where he joined the botanical society directed by Pier Antonio Micheli.
He served the Tuscan Grand Dukes as a doctor, and was appointed commissioner of sanitation in the program to vaccinate for smallpox.
He was supervisor of the Orto Botanico di Firenze in Florence succeeded by Saverio Manetti.
He had varied interests including writing about ways to prevent the Arno from flooding and about local archeologic artifacts.
After the age of catastrophe, to give strong evidence on geomorphological activities occurring on earth, he postulated that the irregular courses (symmetry and asymmetry of the valleys) of the rivers depended on the nature of rocks through which they flow.