She also had supporting roles in the films Scream 2, Friends 'Til the End, Can't Hardly Wait, Jane Austen's Mafia and The Sex Monster.

In 2003, she made guest appearances on episodes of Friends, CSI: Crime Scene Investigation, Law & Order: Special Victims Unit, Nip/Tuck and Charmed.

She appeared in NCIS: LA in 2010, as Tracy Keller, former partner and potential romantic interest for Special Agent G. Callen (Chris O'Donnell) in the sixth episode of Season 2.

[7] In NCIS, she appeared as ATF Special Agent Zoe Keats, the girlfriend of Tony DiNozzo (Michael Weatherly) for several episodes of season 12.

In 2012, Nichols starred in the ABC TV series GCB, with Leslie Bibb, Kristin Chenoweth, Annie Potts, Jennifer Aspen and Miriam Shor.

[17] In 2012, as her career slowed down, Nichols began working with former FBI and CIA agents, Navy SEALs and Green Berets,[18] as well as local law enforcement who have left government agencies and gone independent to help trap child sex predators.

[17] In partnership with nonprofit organization Operation Underground Railroad, Nichols' work took her across the United States and other countries globally, including Haiti and Venezuela.