[1] She is best known for portraying Tiffany "Pennsatucky" Doggett in the Netflix original series Orange Is the New Black (2013–2019),[2] Cherry in Sons of Anarchy (2008–2010), Nola in Hustle & Flow (2005) and Janeane in 8 Mile (2002).

[5][6] Manning grew up living in a trailer park with her brother and single mother, who supported the family on a strict income: "My mom didn't buy herself a new pair of shoes and a new outfit until I moved out ...

"[7] In spite of the family's financial troubles, her mother was able to enroll Manning in karate, dance, and acting classes.

[6] Manning began acting in the late 1990s, appearing in small roles in several film and television productions, including episodes of The Practice, Get Real, NYPD Blue and Popular.

Along with supporting roles in the films Lucky 13 and Debating Robert Lee, Manning appeared briefly in Anthony Minghella's Civil War melodrama Cold Mountain (2003) and in the romantic comedy A Lot Like Love (2005).

Director Craig Brewer saw Manning's picture in a photography book and was convinced that the actress who played Nola should look just like her.

[citation needed] Subsequent film roles include Unbeatable Harold, When the Nines Roll Over.,[8] and, later, Weirdsville, which co-starred Scott Speedman and Wes Bentley.

[20] In early 2012, Manning signed on to star in the supernatural web series The Unknown, which premiered on Crackle on July 13, 2012.

In 2015 she portrayed Michelle Knight in the Lifetime film Cleveland Abduction based on the real-life events surrounding Ariel Castro's kidnappings.

[23] Music from Boomkatalog.One has also appeared in movies, including Mean Girls, Crossroads, The Hot Chick, 8 Mile and The Italian Job.

After a hiatus, in an interview in October 2005's issue of Nylon magazine, Manning mentioned that she is writing songs for the new album once they find another record label.

In October 2008, Boomkat played several shows throughout the Los Angeles area, hitting spots like North Hollywood's NOHO Scene Festival and venues such as the Viper Room and Hotel Cafe.

In December 2008 Manning recorded a version of Tom Petty's "Christmas All Over Again", which premiered on her official Myspace page.

Her campaign with Frankie B included a short film, called "Let's Get Lost", which is the original song featured in the video by musician Gilby Clarke with vocals by Manning.

[39] She has appeared on the cover of several magazines, including Nylon, Stuff, FHM, Dazed & Confused, 944, Music Fashion, Miami Living and Paw Print.

[43] Manning was aboard JetBlue Flight 292 when it made an emergency landing at Los Angeles International Airport on September 21, 2005, after the nose gear jammed in an abnormal position.

In November 2012, Manning accepted a plea bargain of one day of community service and good behavior for the next six months, after which the case would be closed.

[46][47] In November 2014, Manning was arrested for violating a restraining order and making criminal threats against girlfriend Jeanine Heller.

[49] In 2016, Manning was found to have fabricated contact violations, and as a result Heller had been falsely arrested and imprisoned via forced plea deal.

[50] In 2020 Heller was awarded damages for an undisclosed amount from the Manhattan District Attorney and New York State Supreme Court.

The attack was one of several that Hartman claimed to have suffered, with the most recent alleged abuse occurring in late 2015 at Manning's Manhattan apartment.

[56] A Manhattan judge dismissed the case stating Manning's claims “lacked merit” and no such violation occurred.

[57] In 2019, Manning claimed she was "epically hack[ed]" and the victim of "cyber-criminals" and "cyberbullying" after several disturbing Instagram posts included disparaging remarks about the cast of Orange is the New Black.

[60] In 2016, Orange is the New Black producers threatened to remove Manning from the show and required her to enter a drug rehabilitation facility for treatment after her alcohol use began to interfere with production of the series.