In 1924, an assistant mountain guide named Paul Moser fell to his death attempting to scale Unicorn Peak by a new route.

[6] In 2004, 16-year-old Vasiliy Kozorezov fell and died while hiking off-trail below the Eagle Peak Trail.

In 1946, heavy fog caused park employees Donald Carlson and James Pratt to get lost in the range for two days, but as the weather improved, they were able to find their way back.

[10][11] In 1937, attempts were made to film the movie Thin Ice on location, but blizzards made it impossible, so the crew and actors Tyrone Power and Sonja Henie returned to California to shoot the movie in a studio, while director Dave Butler and a cameraman stayed behind to collect footage of the Tatoosh Range to use for the background images.

[1] Some peaks are able to be reached by hillwalking, while others can only be summited on alpine routes by scrambling and rock climbing.