[4] Like other topical retinoids, such as tretinoin and adapalene, tazarotene can be combined with benzoyl peroxide or an oral antibiotic, such as clindamycin or dapsone, for the treatment of acne.

[12] Because of the lack of pregnancy outcomes data for the drug, the determination was based on the teratogenic effects observed in rat and rabbit studies.

[4] Adverse effects for tazarotene include skin irritation, such as redness, itchiness, and burning.

In patients with psoriasis, these adverse effects can be mitigated by a combined treatment with either mometasone furoate or fluocinonide.

[16] Tazarotene is excreted from the body via feces and urine equally,[9] and it has an elimination half-life of 16[17] to 18 hours.

The formation of the ring system involves first alkylation of the anion from thiophenol with dimethylallyl bromide (1) to give the thioether (2).