It was in a prominent location near the Palazzo Giustinian and the church of San Moisè at the entrance to the Grand Canal.
Built by the San Bernaba branch of the Giustiniani family c. 1620, it was originally a prose theatre.
In the 1770s and 1780s the theatre was under the control of the prolific librettist Giovanni Bertati, the Poeta Cesareo ("Imperial Poet") of the Italian Opera in Vienna, who concentrated on drammi giocosi with Pasquale Anfossi and other composers.
[4] The San Moisè finally closed in 1818 after producing a series of farse by Rossini.
In July 1896, the Minerva saw Venice's first cinema projection when the Lumière brothers brought their equipment to the theatre.