Besides scholarly articles and critical essays, the journal publishes reviews of books and museum exhibitions.

The journal occasionally publishes thematic issues; topics include patents, gender and technology, and ecology.

Technology and Culture has had three past editors-in-chief: Melvin Kranzberg (1959–1981), Robert C. Post (1982–1995), and John M. Staudenmaier (1996–2010).

Managing editors have included Joan Mentzer, Joseph M. Schultz, David M. Lucsko, and Peter Soppelsa.

In its inaugural issue, editor Melvin Kranzberg set out a threefold educational mission for the journal: "to promote the scholarly study of the history of technology, to show the relations between technology and other elements of culture, and to make these elements of knowledge available and comprehensible to the educated citizen."