[1] Brain is known for her eccentric and often purposefully dysfunctional information systems that examine the intersection between digital networks and natural phenomena.

[2][3] Her art works have been discussed widely in press outlets such as The New York Times, The Atlantic, Artforum, NPR and The Guardian.

[1] In 2015, in response to the decision by John Hancock Insurance to offer discounts if members shared their personal fitness data as logged by a Fitbit, Brain, alongside engineer Surya Mattu, created the website Unfit-Bits.

This work aggregates all New York City real-estate listings and presents them as a fictional massive apartment.

The New York Times described the piece as an "archive of well-wishes and fears, prayers and pleadings, represent a slice of the grief, love, medical costs and mutual aid that define illness in this country.