The inauguration ceremony was attended by Prime Minister Yitzhak Rabin and the mayor of Tel Aviv Shlomo Lahat.

[3] The station, which was designed by Ram Karmi (1967) and completed (1993) by the architects Yael Rothshild, and Moti Bodek, opened with six floors, and the initial plan called for buses to travel to all six.

[3] On 24 October 2021, the Tel Aviv Court for Local Affairs has issued a closure order for the New Central Bus Station from December 2021.

Consequently, the Tel Aviv-Yafo Municipality and the Israel Fire and Rescue Services have told the store owners that they would have to close from 5 December and the bus companies would also have to make alternative arrangements.

That move is to be sped up because the Fire Service has refused to give the Central Bus Station a license to operate.

On the 7th floor, which was an addition to the original building, there is a departure hall for local buses (to destinations within Gush Dan) on the north wing, and another departure hall for intercity buses (to destination in the Galilee) on the south wing.

As the station is located in the poorest part of the city, numerous drug addicts, prostitutes and homeless people take residence there on occasion.

[3] The station has also been criticized for its complicated design which makes it hard to get around, and for being built in a neighborhood that didn't fit its character.