Telangiectasias, aside from presenting in many other conditions, are one of the features of the acronymically named CREST syndrome, a form of systemic scleroderma.

The syndrome recognises the significantly co-presenting symptoms of calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia.

[4][full citation needed] Telangiectasia in the legs is often related to the presence of venous reflux within underlying varicose veins.

Factors that predispose to the development of varicose and telangiectatic leg veins include Acquired telangiectasia, not related to other venous abnormalities, for example on the face and trunk, can be caused by factors such as Before any treatment of leg telangiectasia is considered, it is essential to have duplex ultrasonography, the test that has replaced Doppler ultrasound.

Sclerotherapy is the "gold standard" and is preferred over laser for eliminating telangiectasiae and smaller varicose leg veins.

[18][19][20] Varicose veins can be treated with foam sclerotherapy, endovenous laser treatment, radiofrequency ablation, or open surgery.

[citation needed] Other issues which arise with the use of sclerotherapy to treat spider veins are staining, shadowing, telangiectatic matting, and ulceration.