Tellimagrandin I is an ellagitannin found in plants, such as Cornus canadensis, Eucalyptus globulus, Melaleuca styphelioides, Rosa rugosa, and walnut.

It is composed of two galloyl and one hexahydroxydiphenyl groups bound to a glucose residue.

Tellimagrandin I has been shown to restore antioxidant enzyme activity in glucose- and oxalate-challenged rat cells[1] and affects Cu(II)- and Fe(II)-dependent DNA strand breaks.

[2][3] It has hepatoprotective effects on carbon tetrachloride- and d-galactosamine-stressed HepG2 cells[4][5] and enhances peroxisomal fatty acid beta-oxidation in liver, increasing mRNA expression of PPAR alpha, ACOX1, and CPT1A.

[6] It enhances gap junction communication and reduces tumor phenotype in HeLa cells[7] and inhibits invasion of HSV-1[8] and HCV similar to eugeniin and casuarictin.