In 2011, the science centre moved locations from the former Centennial Planetarium to the Nose Creek Valley.

The science centre originally opened as the Calgary Centennial Planetarium on July 1, 1967.

The original site, located on 11 Street SW in Calgary's Downtown West End, closed on June 27, 2011, and was replaced by a new science centre called Telus Spark.

The new science centre is located on a 15-acre (61,000 m2) site at 220 St. Georges Drive NE in Nose Creek Valley, north of the Wilder Institute/Calgary Zoo.

[3] In response to the COVID-19 pandemic, Telus Spark was awarded $381,414 by the Government of Canada to promote uptake of COVID-19 vaccines among indigenous youth, communities and leaders using online education and hip hop music.