It goes southward as Green Grove Road and passes through the mountains of the Highland Rim before entering farmland and crossing into Trousdale County.

SR 141 then splits off of US 70/SR 26, where it switches cardinal directions from north–south to east–west, and heads east as Trousdale Ferry Pike while running parallel to I-40.

It then crosses Smith Fork Creek and enters the small community of Lancaster as the road is generally heading east.

After leaving Lancaster, SR 141 abruptly turns south-southwestward and closely parallels the Caney Fork River as it enters DeKalb County.

SR 141 continues east as Wolf Creek Road through hilly terrain before crossing into Putnam County.