The road begins 4.1 miles (6.6 km) NE of Dowelltown and ends in Elmwood.

After leaving Temperance Hall, SR 264 travels roughly northward and enters Smith County.

After entering Smith County, SR 264 becomes Temperance Hall Highway, passing through Hickman.

Upon entering Gordonsville, the old alignment of Hickman Highway splits off and continues north into town, while SR 264 turns northwest along a two-lane bypass known as Hatton Waterford Parkway.

They travel east as Main Street through Gordonsville before SR 264 splits off and continues northeast.