They then go north as a 2-lane highway through flat farmland before crossing the Elk River and going through Estill Springs, where it has an intersection with SR 279 and passes by the Arnold Air Force Base and the Woods Reservoir before crossing the Coffee County line and entering Tullahoma.

US 41A/SR 16 then immediately enter downtown Tullahoma after crossing into Coffee County, where they intersect and become concurrent with SR 55/SR 130.

In Bedford County, US 41A/SR 16 then turn west and pass just south of Normandy before having an intersection with SR 276.

US 41A/SR 16 then continue through some suburban areas and pass by an industrial park before entering downtown and having an intersection with US 231 Business/SR 10/SR 82.

After crossing into Williamson County, US 41A/SR 16 then continues for a very short distance before coming to a Y-intersection with US 31A/SR 11 in Kirkland, just north of College Grove and just south of I-840 and Triune.