It connects Trezevant and South Fulton via Pillowville, Gleason, Palmersville, and Latham.

It heads north to cross the South Fork of the Obion River to pass through rural areas before entering Weakley County.

[2] The highway winds its way north through farmland to pass through the community of Pillowville, where it has an intersection with SR 124.

It then has an intersection with SR 22 before leaving Gleason and continuing east, then north, to pass through wooded areas, where it crosses a bridge over the Middle Fork of Obion River.

[3] SR 190 becomes McConnell Road as it turns southwest to come to an end at an intersection with US 45E/SR 43 between South Fulton and Martin.