It then has an intersection with SR 108 before going through downtown and leaving Whitwell to go down a long, narrow valley full of farmland.
The highway now passes through Palio, Lusk, and Lees Station before entering Pikeville at an intersection with SR 30.
They then become concurrent with each other to bypass downtown as a 4-Lane undivided highway before splitting off to the west, with US 127/SR 28 narrowing back to 2-lanes and continuing north through farmland to pass through Cold Spring and Melvine before pulling away from the Sequatchie River and ascending onto the Cumberland Plateau and entering Cumberland County.
The highway now passes through Cumberland Homesteads, where it has a y-intersection with SR 68, and US 127/SR 28 turn northeast to enter Crossville.
US 127/SR 28 then have an intersection with US 70N/SR 24 before going through Crossville's main business district before crossing the Obed River and coming to an interchange with I-40 (Exit 317).
They then cross into Fentress County via a couple of sharp switchbacks, in order to negotiate a bridge over Clear Creek.