SR 95 serves as a secondary route between its southern terminus in Greenback and I-40 and as a primary highway for the rest of its duration.

Curving through the Red Knobs, it passes through the communities of Centersville and Glendale, before reaching US 321 (SR 73).

Crossing the Clinch River, via the Charles Vanden Bulck Bridge, SR 95 enters Roane County and land controlled by the Department of Energy/Oak Ridge National Laboratory.

It exits the Department of Energy's boundary near the Roane/Anderson county line, soon after neighborhoods begins to appear just off the road and bike lanes are along the shoulders.

[3] In Anderson County, SR 95 serves as the main highway through Oak Ridge, with commercial businesses along its shoulders and neighborhoods connected by access roads.