Several real-life models served as inspiration for the main character, starting with Rena Mero at launch,[1] then later Cindy Margolis or Farrah Fawcett.

Lead character Emma Sonnet returns after disappearing eight years before, with no answers for former best friends Brett and Dawn about where she has been and how she has become the until-now unheard-of tenth sister of the mythological nine Muses, the inspirational daughters of the almighty Zeus.

In 2005, the series was relaunched as The 10th Muse Volume 2 with a new #1 issue, starting publication in April from Alias Enterprises.

In 2009, a new personification of the character was released in a four-issue limited series called "Tenth Muse 800" set eight hundred years in the future.

The crossovers featured the 10th Muse and Shi, Savage Dragon, Tellos, Koni Waves and Ezra.