That work culminated in a report called Preparing for the Future of Artificial Intelligence, which detailed opportunities, considerations, and challenges in the field of AI.

[9] In 2017, Lyons was recruited to lead the Partnership on AI, a research and policy organization founded by Facebook, Google, Microsoft, and a number of other technology corporations.

[1][10] The mission of the nonprofit organization is to research and provide thought leadership around the direction of AI technologies, including machine perception, learning, and automated reasoning.

[11][12] Lyons has testified in front of the House of Representatives Oversight & Government Reform Committee Subcommittee on Information Technology to discuss the promise of artificial intelligence and advocate for the importance of the Partnership on AI.

In 2018, she spoke at The New York Times new work summit about why inclusion is a crucial issue to address in the fields of computer science and AI especially.