[3] Ganzel was a recurring cast member of The Tonight Show Starring Johnny Carson as the Matinee Lady in the "Tea Time Movie" sketches.

She has often played stereotypical ditzy blonde bimbo roles, including Greedy Gretchen in the Three's Company episode "Lies My Roommate Told Me" (1981), National Lampoon's Movie Madness (1982), the film The Toy (1982) with Jackie Gleason and Richard Pryor, and the Married... with Children episode "A Three Job, No Income Family" (1989).

[citation needed] In 1984, Ganzel played another young and ditzy blonde, Sheree Winkler, in the short-lived sitcom The Duck Factory, which introduced Jim Carrey to American audiences.

[citation needed] Ganzel has had several voice-over roles in cartoons, animated movies, and series, including Cow and Chicken, The Emperor's New School, Monsters, Inc., Goof Troop, Aaahh!!!

Ganzel voices Miss Vavoom, the 1990s revival of Red Hot Riding Hood, in Tom & Jerry Kids and Droopy, Master Detective.