Barry Gibb had heard her demo of original music and was so inspired by DeSario's vocals that he wrote a song for her called "Ain't Nothing Gonna Keep Me from You" and helped her obtain a recording contract.
"Ain't Nothing Gonna Keep Me from You" from 1978 was DeSario's first hit single, written by Barry Gibb from her first album Pleasure Train, also released in 1978.
Follow-up singles (album title track) "Moonlight Madness" and a remake of "Dancin' in the Streets" charted but didn't make the Billboard Top 40.
By the end of 1980, her hit "Yes, I'm Ready" granted her one-hit wonder status, with the disco-era making an exit, even though her duet with KC was a pop-fused remake of a slow-dancing ballad.
DeSario would also provide vocals on Mark Snow's 1996 album, The Truth and the Light: Music from the X-Files In 2012, Gold Legion.com digitally remastered Pleasure Train and released it on CD.
[citation needed] In the late 1970s/early 1980s, DeSario made TV appearances including American Bandstand with Captain and Tennille and KC (December 29, 1979), The Midnight Special with Tom Jones (February 8, 1980) and on Solid Gold hosted by the Pointer Sisters (January 17, 1981).