The key personnel who helped bring this hit recording to life later became the important creators of the "Philly Sound".

These people include: Kenny Gamble as a backup singer, Bobby Eli and Norman Harris on guitar, Ronnie Baker on bass and Earl Young on drums (Eli, Harris and Baker later on became principal members of MFSB and Kenny Gamble would co-found Philadelphia International Records with Leon Huff).

2 on the Billboard Hot 100 chart in March 1980, kept from the summit by "Crazy Little Thing Called Love" by the rock group Queen.

"Yes, I'm Ready" has been covered by other artists, including Mona Carita (fi) (as "Tahdon"), Shirley Ellis, Gladys Knight & the Pips, Maureen McGovern, Jeffrey Osborne, and Carla Thomas.

Chicago's hit "Beginnings" ("Live at Tanglewood" version) includes the line "I don't even know how to hold your hand" from "Yes, I'm Ready".