It is on the Florence–Rome railway and the line to Foligno (which passes through Perugia) branches off from the station.

There is also two freight loading areas; The station also has several other service buildings including an office for train control, where various Apparato Centrale Elettrico a Itinerari (an Italian system for controlling train movements at stations) desks are located.

Although traffic significantly decreased after the opening of the Florence–Rome high-speed railway, the number of passengers and trains is always at a high level, increased by interchange between the two lines.

The station is managed by RFI, which classified it in 2008 in the silver category.

[1] It has: Etruria Mobilità buses leave from the square in front of the station for the centre of Cortona.