He is best known for his work on titles such as Harley Quinn, Trouble, Spider-Man/Black Cat: The Evil that Men Do, Marvel Knights: Spider-Man, Wonder Woman and Uncanny X-Men.

In early 1996, he drew a four issue Storm mini series (starring the X-Men character of the same name), which was written by Warren Ellis, inked by Karl Story and published by Marvel Comics.

In 2000, Dodson left Marvel for DC Comics where he pencilled a Harley Quinn ongoing series written by Karl Kesel.

Dodson returned to Marvel in 2002 to draw Spider-Man and the Black Cat: The Evil that Men Do, a limited series which was not completed until 2006 due to delays.

In 2003, Dodson and writer Mark Millar produced a controversial limited series titled Trouble, which was published through Marvel's Epic Comics imprint.