Dean Seagrave (David Sutcliffe) is a thirty-something graphic novelist living in L.A., and though he's found personal happiness with his boyfriend Pablo (Antonio Sabato Jr.), he can't surmount his writer's block slump following his successful debut graphic novel, Teenage Speed Freak.

His life begins to unravel when his editor, Luise (Coolidge), gives him an ultimatum and Pablo leaves him.

Lonely, depressed, and at the end of his rope, Seagrave flies to Argentina in search of closure, but the characters he discovers there – Pablo's secretive and controlling Mother (Sônia Braga), Pablo's ex-lover Marcos (Leonardo Brzezicki), and Marcos' enigmatic sister Sofia (Celina Font) – conspire to prevent him from reaching Pablo.

Although the setting for the story of Testosterone starts in Los Angeles, California and then moves to Buenos Aires, Argentina, the Los Angeles scenes were filmed in Buenos Aires and the Buenos Aires scenes were filmed in Los Angeles.

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