Tetradymia stenolepis is a species of flowering plant in the aster family known by the common name Mojave cottonthorn.

[1] It is native to the deserts around the intersection of Arizona, Nevada, and eastern California, where it grows in woodland and scrub habitat on sandy and gravelly substrates.

It is a bushy shrub with many branches coated in woolly white fibers and growing to a maximum height just over a meter.

The narrow leaves are 2 or 3 centimeters long and harden into straight, sharp spines.

The inflorescence bears up to 7 flower heads which are each enveloped in four or five woolly phyllaries.