SH 115 begins at an intersection with Interstate 20 and Farm to Market Road 1927 in Pyote.

The route travels north along the eastern edge of town and through Far West Texas oil fields before reaching Wink.

The route travels through downtown Kermit, passing the Winkler County Courthouse.

The route continues northeast, crossing through the intersection of Andrews, Gaines, Martin, and Dawson Counties before reaching its terminus at SH 349 at the unincorporated community of Patricia, Texas.

SH 115 was originally proposed on July 13, 1926 as a route from north of Amarillo to Stratford into Oklahoma.