The highway begins with a concurrency with US 281/US 380/SH 114, with US 380/SH 114 leaving just south of the Jacksboro city limits.

The highway travels southeast to the town of Joplin, where it intersects with Farm to Market Road 1156.

SH 199 travels through the town of Lake Worth as a divided highway with a wide median until reaching Interstate 820 at a modified cloverleaf interchange.

Just inside Interstate 820, SH 199 enters the city limits of Fort Worth and intersects State Highway 183 just northeast of River Oaks.

SH 199 crosses over both the West and Clear Forks of the Trinity River and enters Downtown Fort Worth.