Leaving San Angelo, the highway's route becomes rural and sparsely populated, traveling by several farms and ranches.

In Robert Lee, the highway intersects Loop 229, SH 158, and Farm to Market Road 1904, with the latter providing access to the north end of the E.V.

In northern Coke County, the highway bypasses the unincorporated town of Silver, with RM 1672 providing direct access to the community.

SH 208 crosses over the northeast section of the Champion Creek Reservoir then enters into Colorado City.

North of Snyder, the highway's route becomes extremely rural and enters into Kent County.

[3] The section from Robert Lee to Colorado City was dropped on March 26, 1942, but was reinstated on April 23, 1947, when it replaced RM 18.

SH 208-B overlaps I-20 BL with the two highways traveling in a western direction along Westpoint Avenue and 2nd Street.

The highway travels through densely populated areas of the town before ending at I-20/SH 208 in northern Colorado City.