State Highway 290 (SH 290) is a state highway maintained by the Texas Department of Transportation (TxDOT) that runs from Interstate 10 near Sheffield east to another connection with I-10 about 20 miles (32 km) east of Sheffield.

The route connects I-10 to Sheffield and Fort Lancaster State Historic Site and overlays a portion of SH 349.

[1][7] US 290 together with US 80 formed a route linking El Paso to Austin and Houston before the construction of I-10.

SH 290 then runs southeast to the Pecos River where the road enters Crockett County.

The road then turns northeast climbing steeply out of the river valley and returns to I-10 at Exit 343.