SH 352 travels in a southeastern direction along Robert B. Cullum Boulevard on the southwestern edge of the State Fair of Texas.

SH 352 crosses over White Rock Creek and travels through a less densely populated area of the city in the Parkdale neighborhood.

SH 352 intersects I-635 (Lyndon B. Johnson Freeway) then travels through a less developed part of Mesquite with industrial areas until reaching Carmack Street.

Leaving the downtown area, SH 352 travels along the northern boundaries of Mesquite High School and E. H. Hanby Stadium.

In Sunnyvale, the highway's name becomes South Collins Road and the route becomes more developed with commercial areas and restaurants.