East of I-635, the US 80 freeway serves as the northern terminus of SH 352, the main highway into downtown Mesquite.

Though there is no business loop through Forney proper, FM 688, which runs the entire length of Broad Street through town, serves a similar function.

[4][7][8] A pair of frontage roads services the entire US 80 segment of the freeway, except for a small area west of Forney, where US 80 crosses a bridge over the East Fork Trinity River.

The highway runs in mostly a straight line from Terrell to Mineola, where it intersects US 69 about 30 miles north of Tyler.

[9] Nationally, US 80 ran from Savannah, Georgia to San Diego, California, being a major transcontinental highway.

Between 1964 and 1989, US 80 was decommissioned entirely within California, Arizona and all of New Mexico outside of Anthony (which is located near the Texas state line).

In 1991, the remainder of US 80 in both New Mexico and Texas west of Dallas was decommissioned, bringing the national western terminus to its current location.