It runs from Amarillo Boulevard (Interstate 40 Business) and Bell Street east along 9th Avenue, Bushland Boulevard and 6th Avenue to end at Fillmore Street (northbound U.S. Route 87).

The road soon becomes a five-lane road with a center left-turn lane as it passes through commercial areas before heading between the Amarillo Country Club to the north and residential areas to the south, losing the center turn lane.

The highway turns northeast onto Bushland Boulevard at this point and continues south of the golf course.

Loop 279 narrows into a two-lane road and heads past businesses, turning east onto SW 6th Avenue.

The highway heads into the commercial downtown of Amarillo, widening into a four-lane road.