There is little development along the route at first, before seeing an increase in between University Avenue and Farm to Market Road 3379 (FM 3379, Houston Street) near Wiley College.

Loop 390 intersects U.S. Highway 80 (US 80, W. Grand Avenue), FM 449, and SH 154 just west of East Texas Baptist University.

Near County Road 2100, Loop 390 starts to turn towards the south and has an interchange with SH 43 (Karnack Highway) in the eastern part of the city.

Loop 390 runs in a slight southeast direction before ending at an intersection with US 80 (Victory Drive) near the city's eastern edge.

Loop 390 will be extended south from US 80 east of Marshall southward to I-20 and will be built to Interstate standards in anticipation of a future I-369 designation.