Spur 450 begins at a junction with SH 302/Loop 338 in West Odessa.

The highway travels in a southeast direction down Kermit Highway and enters Odessa near an intersection with FM 1882.

Spur 450 ends at an intersection with US 385 just north of downtown Odessa.

Spur 450 was designated on September 26, 1967 along the current route.

[2] The entire route is in Ector County.