[2] On February 12, 1943, an 0.4 mile extension across the hatchery property to a connection with the Uvalde-Eagle Pass County Road was proposed.

Signage indicating that state maintenance ends is present east of the Sand Dollar Boulevard entrance to TAMU–CC.

It has a brief concurrency with I-45 until that route's exit 44B, at which point it travels south as a freeway with frontage roads, passing the eastern side of the University of Houston campus.

The mainlanes end prior to the intersection with University Drive, while the frontage roads continue to the route's southern terminus at US 90 Alt.

[9] The first use of the Spur 5 designation was in Hays County, from US 81 west 0.2 miles (0.32 km) to Burleson Street in Kyle, as a replacement of a section of Loop 5.

[23] Locally named Ponderosa Lane, Spur 17 continues as a rural, two-lane road along the northern boundary of Dalhart.

On May 19, 1942, the route was extended along Burlington Avenue to reconnect with SH 70 north of Spur, and the designation was changed to Loop 21.

[36] The original Spur 22 was designated on September 26, 1939, from US 380 south along Central Avenue to an intersection with Mesquite Street in Peacock.

[2] On October 14, 1946, the road was extended north 2 miles (3.2 km) to the Lorenzo Cemetery;[47] the entire route was added to FM 378 but still designated as Spur 26.

[50] Spur 28 begins at an intersection with SH 35 northeast of Angleton, heading southeast on the two-lane, undivided Main Street.

Past this intersection, Main Street continues as an unnumbered road into the center of the city, crossing over the Union Pacific Railroad.

It runs along I Road, from US 281 at the southeastern city limits of Pharr to the proposed Border Safety Inspection Facility north of the Pharr–Reynosa International Bridge.

On December 18, 2014, Spur 53 was scheduled for removal from the state highway system as part of TxDOT's San Antonio turnback program, which gave 21.8 miles (35.1 km) of roads to the city.

The next use of the Spur 55 designation was in Harris and Chambers counties, from SH 146 in Baytown east across Cedar Bayou to FM 1405.

Spur 63 was designated on August 27, 1958, from SH 26 (now US 259) near the west side of Longview north across a Texas and Pacific Railroad rail line to US 80 near Tutt Street.

The original Spur 63 was designated on September 25, 1939, from SH 31 to the St. Louis Southwestern Railway of Texas rail line in Malakoff.

Spur 64 was designated on September 25, 1939, from SH 31 to the St. Louis Southwestern Railway of Texas rail line in Trinidad.

The next use of the Spur 66 designation was in Bexar County, from SH 16 southeast 1.5 miles (2.4 km) to Applewhite Road (Toyota headquarters).

It runs from SH 75 (former US 75), 3 miles (4.8 km) north of the Walker County line, northeast to I-45 at South Connor Road.

Spur 69 was designated on January 21, 1969, from I-35 west along Airport Boulevard to Koenig Lane near a Southern Pacific rail line.

On January 31, 1972, the road was extended west 0.7 miles (1.1 km) to Lamar Boulevard (then Loop 275) and was signed as RM 2222 rather than Spur 69.

On May 5, 1966, a section was added to serve the La Bahia Mission area and the route was changed to Loop 71.

The first use of the Spur 72 designation was in San Patricio County, from US 181 near northwestern Sinton to SH 96 north of Chillipin Creek.

It runs from exit 212 on I-30 through Leary to US 82 near Victory City, at the entrance to the now-deactivated Lone Star Army Ammunition Plant.

At its terminus at the summit of Mount Locke, Spur 78 has the highest elevation at any point on the state highway system, at 6,791 feet (2,070 m).

From FM 493 in southern Donna, it will run westward and northward 3.3 miles (5.3 km) to the future SH 68.

Spur 85 was designated on December 18, 1939, from SH 21, 4 miles (6.4 km) west of San Augustine, to the monument commemorating the spot where the first Presbyterian Church was established in Texas.

Spur 92 was designated on May 9, 1940, from US 77 south of La Grange to the tomb of the men of the Mier expedition and Dawson massacre as a redesignation of SH 167.

The 1.1-mile (1.8 km)[126] rural route proceeds northward along gentle grades to a point near the confluence of Stevens Creek with the Guadalupe River.

The next use of the Spur 99 designation was in Cameron County, from SH 345 northwest 0.7 miles (1.1 km) to Combes Street in San Benito.