Though no trains originate from this station, trains halting at the station connect the city to prominent cities in India such as Thiruvananthapuram, Kochi, Chennai, Mumbai, Bangalore, Kozhikode, Coimbatore, Quilon, New Delhi, Mangalore, Pune, Jaipur, Jammu Tawi, Okha and so forth.

[citation needed] Thalassery railway station once had goods transportation facility.

No direct line connects Thalassery to Mysore, although a feasibility study for such a route was funded in 2013.

Almost all major trains connecting the other parts of Kerala, Tamil Nadu, Andhra Pradesh and North India halt here.

The station is also equipped with free wireless internet access facility, and prepaid auto stand.