Thale Hauptbahnhof is a station on the Magdeburg–Thale railway in the town of Thale in the German state of Saxony-Anhalt.

Formerly, when locomotives were repositioned from one end of the train to the other, it was necessary to close the two crossings near the station.

Today, however, the line is only operated with diesel multiple units.

The station is served hourly by the Harz-Elbe-Express.

On weekends the Harz-Berlin-Express runs without a change of trains to/from Berlin Ostbahnhof, operating on Fridays to Sundays from Thale to Berlin once a day and from Berlin to Thale once on Saturdays and twice on Sundays.