That Fatal Sneeze is a 1907 British silent comedy film, directed by Lewin Fitzhamon and starring Thurston Harris and Gertie Potter.
Before he can request assistance, the uncle sneezes violently again, which knocks over the policeman and a lamppost, as well as causing damage to a house.
In an attempt to escape the crowd that is pursuing him, the uncle climbs up a ladder, but this breaks when he sneezes again.
The film contains a number of primitive special effects, including the use of wires to move objects when the uncle sneezes, and the balancing of the camera on a rocking board to give the impression that the world is swaying in the penultimate shot.
The dramatic final scene, in which the uncle explodes, was achieved by stopping the camera and replacing the actor with a small smoke-emitting device.