The show originally ran from 19 May 1956 to 18 January 1958 produced by ATV and was originally hosted by Jerry Desmonde, and called simply The 64,000 Question with the top prize initially being 64,000 sixpences (£1,600), later doubling to 64,000 shillings (£3,200).
After a successful pilot was shot on 15 November 1989, the programme was revived from 1 June 1990 to 29 August 1993 with Bob Monkhouse as the host and a higher £6,400 top prize.
Jerry Desmonde was the host and former Detective Superintendent Robert Fabian was "custodian of the questions".
£3,200 was higher, in real terms (i.e. accounting for inflation), than anything on offer on British TV for most of the 1960s, 1970s and 1980s, after the Independent Television Authority (later the Independent Broadcasting Authority) imposed prize limits on game shows after the general discrediting of the genre following the quiz show scandals in the US and rumours that the British version of Twenty-One was also corrupt.
In 1993, prize limits were lifted by the Independent Television Commission (paving the way for the eventual arrival of Who Wants to be a Millionaire?