The film stars the voices of Oscar Isaac, Charlize Theron, Chloë Grace Moretz, Nick Kroll, Javon Walton, Wallace Shawn, Snoop Dogg, Bette Midler, and Bill Hader.

Back at the Addams' home, Gomez worries that the children are drifting apart from him and Morticia, so he decides to take them on a family vacation.

Before the family, Fester, Thing and Lurch head on a road trip across the United States, Gomez and Morticia are approached by a lawyer named Mr. Mustela, who claims that Wednesday was switched at birth and may not actually be an Addams, but they ignore him.

The family is initially set on going to Salem, Massachusetts, but Fester, who is slowly mutating due to the experiment, ends up making a detour to Niagara Falls.

Fester is turned back to normal by Wednesday, using a necklace of her family's blood that Morticia gave her earlier.

[5] Cinesite Studios was again a production partner on the film and provided CG animation and digital visual effects for the sequel.

[14] In August 2021, the film shifted its release for online rental to the same day as its theatrical bow in the United States and Canada, due to the COVID-19 pandemic.

[2][3] In the United States and Canada, The Addams Family 2 was released alongside Venom: Let There Be Carnage and The Many Saints of Newark, and was projected to gross $15–17 million from 4,207 theaters in its opening weekend.

"[21] Metacritic assigned the film a weighted average score of 37 out of 100, based on 23 critics, indicating "generally unfavorable reviews".

[18] Owen Gleiberman of Variety wrote about the film "It's in the nature of most animated sequels to struggle to recapture the full charm of the original hit.

"[24] Nell Minow of RogerEbert.com gave a 3 out of 4 stars and wrote, "An intrusive product placement billboard will trigger the irritation viewers may have with the odd cross-promotion in television commercials on behalf of both this movie and an insurance company.

Of more concern, parents may get some tough questions due to the paternity issues raised by the film, including DNA tests.

"[25] Sandie Angulo Chen of Common Sense Media gave the film 3 stars out of 5 and wrote "Silly sequel focuses on family love; peril, some racy jokes.

"[26] Meagan Navarro of Bloody Disgusting gave 2 bones out of 5 and wrote "The Addams Family 2 might change its scenery, but it doesn't deviate from its approach.

"[27] Molly Freeman of Screen Rant called the film "[...] a shallow continuation that spends too much time on unconnected hijinks resulting in an uneven sequel with much less heart.

"[28] Mychael and Jeff Danna won Best Original Score in an Animated Film at the 12th Hollywood Music in Media Awards.