The show follows an 11-year-old genius from the fictitious town of Retroville, Texas the eponymous character, as he goes on adventures with his best friends Carl Wheezer and Sheen Estevez.

The series features voices of Debi Derryberry (Jimmy), Rob Paulsen (Carl), and Jeff Garcia (Sheen) for the three main characters.

The show follows a scientifically minded boy named Jimmy Neutron from Retroville, Texas[6] who frequently goes on adventures with his two best friends, Carl and Sheen, usually involving his inventions going wrong.

There have also been three tie-ins with special episode crossovers involving the Nickelodeon hand-drawn style series The Fairly OddParents under the title "The Jimmy Timmy Power Hour" (the first alone, the second and third with the subtitles "When Nerds Collide!"

[8] The pilot involves Jimmy Neutron testing a rocket ship that he has invented, and later uses it when he inadvertently stumbles upon a Yolkian plot to conquer Earth.

In it, Jimmy wore a red and white striped shirt and did not wear his signature red atom shirt, Judy's hair was darker, Hugh wore a blue suit (instead of a sweater vest and tie) and was a bit smarter, the Yolkians all wore grey suits and King Goobot's crown was a different color, the theme song was longer with a few lines that were cut later, Goddard was voiced by Nathan Lane, Carl Wheezer had a very different design, main characters Sheen Estevez, Cindy Vortex, and Libby Folfax were absent and the title card had a picture in the scene.

Midway through the first season, Jed Spingarn was promoted to Co-Producer and started writing fewer episodes, while Gene Grillo took his place as story editor.

DNA Productions retooled their pipeline when moving from the film to the TV series, to reuse assets for the episodes.

[13][14] Joly Herman of Common Sense Media gave the series 3 out of 5 stars; saying that, "Jimmy Neutron has all the trappings of a Nickelodeon show: the preteen peer pressure, the gadgets, the spacey parents.