[2][9] A version for the Wii U was released in March 2013 in North America and Europe known as The Amazing Spider-Man: Ultimate Edition in both regions.

Meanwhile, the new Oscorp CEO, Alistair Smythe, attempts to develop his own cure so that he will be credited as the city's savior, and to eliminate Spider-Man and Connors for interfering with his plans.

Upon its release, the game received mixed to positive reviews from critics, with praise to the gameplay, controls, combat, dark tone, intensity and soundtrack, although it received criticism for its mode of difficulty, story, visuals, repetitive side missions and lack of innovation.

The Amazing Spider-Man is a third-person video game, set in an open world based on Manhattan.

The game introduces a bullet time mechanic called Web Rush, where players slow down time by holding a button and can select between different locations that Spider-Man will automatically move towards once the player releases the button.

[13] The game's side missions include stopping petty crimes, car chases, and gun fights in the streets, recovering missing patients from a psychiatric hospital that escaped early on in the main storyline, and transporting civilians infected by the cross-species virus to quarantine camps.

Finding this evidence rewards the player with XP Points, or extra content in the main menu, such as concept art.

The player can remove a utility belt from the default suit, which holds some extra web fluid.

A party hat for "Spidey's 50th anniversary" becomes available if the player changes the date of their console or PC to August 10, 2012.

For example, the Rhino Challenge downloadable content (DLC) pack adds the classic Spider-Man suit from the Sam Raimi film series and a mini-game where the player controls Rhino as he rampages through the streets of Manhattan, and the Lizard Rampage DLC pack adds the Vigilante suit from the film and a mini-game where the player controls the Lizard as he fights Oscorp mercenaries and destroys beacons across the city.

Due to the lack of free roam within these versions of the game, players cannot find comic book pages or take pictures of hidden spider graffiti to unlock more suits.

Months after the events of the film, Peter Parker and Gwen Stacy sneak into the restricted areas of Oscorp after hours to investigate rumors of the company continuing Curt Connors' cross-species experiments.

Donning his Spider-Man suit, Peter gets the infected to quarantine, but fails to stop the cross-species from escaping into the city.

Spider-Man and Connors set up a laboratory at the apartment of Aunt May's friend Stan, and begin development of an antidote while keeping in close contact with Gwen and Smythe via webcam, unaware that Smythe is developing his own "cure" using nanobots that destroy the host from the inside out.

After defeating Rhino, one of the escaped cross-species, Spider-Man retrieves Connors' research from a secret Oscorp lab before it gets destroyed.

While there, he meets Whitney Chang, an undercover investigative reporter, who enlists Spider-Man's help in unveiling Oscorp's suspicious activities.

As the CDC quarantines the city due to the advancement of the virus and Connor begins work on replicating the antidote, Spider-Man returns to his heroic activities, foiling a bank robbery orchestrated by Felicia Hardy.

Spider-Man escapes and makes his way across a Manhattan consumed by chaos to reach Connors' secret lab, where he reunites with him and Gwen.

Along the way, he encounters and defeats Natie, the piranha cross-species, and saves Gwen, who has reprogrammed a Hunter to administer Connors' antidote across the city.

During New York Comic Con a producer at Activision, Doug Heder stated that the game would take place after the events of the film.

[16] Dee Brown of Beenox felt that the film was an inspiration of the development of the video game on how the creators wanted it to turn out: "The fact that our game is based on the movie, and the movie is re-approaching the universe in a completely different way — a more grounded, more realistic approach — gives us an incredible setting to play with".

It is a port of the PlayStation 3, Xbox 360 and the PC versions, and features all downloadable content installed onto the disc.