[2][3] Sophia Del Pizzo stars as Lisa Templeton, a young woman who is hired to work as a custodian at High Hopes Psychiatric Hospital, an asylum that was built on the site of a haunted house in Amityville, New York.

Lisa is given a tour of the hospital by the maintenance man, Delaney, and told that she will be responsible for cleaning Ward X, a wing which houses criminally insane murderers like the sexual sadist Jerry Kimble, cannibalistic vigilante Dennis Palmer, occultist Sadie Krenwinkel, and a "Patient X" who is implied to be DeFeo.

On her first night working at the hospital, Lisa encounters the ghost of Allison DeFeo, she is reprimanded for reporting this to the incredulous head of security, Hardcastle, and is sexually harassed by an orderly named Pemberton.

Lisa researches the history of Amityville and discovers that, back in the 18th century, the Satchem, a Native American cult, settled in the area after being run out of Salem by Christians.

[6] John Marrone of Bloody Disgusting found The Amityville Asylum to be mediocre at best, offering mild praise to its performances while noting that its violence was anemic and its story was weak, and that all in all it felt like it was "pasted together on the fly with novice experimentation.