A team made up of Nidhi Vedala, Harold Odhiambo, Peng Wu, Eduardo Brink, and Sophie Kline are selected to investigate the anomaly.

The group's travel towards the anomaly is met with disaster when local tribesmen attack during the night in a strangely violent manner.

Development of the book began when Crichton's widow, Sherri, chose to approach a writer to pen a sequel to The Andromeda Strain.

She cited her reason as "that I don’t want Michael’s classic body of work to be forgotten.” Writer Daniel H. Wilson was approached to write the sequel and Sherri retained final approval of the book before publication.

[4] The Washington Post noted that "Predictable as this group is, their adventure is at least as exciting as Crichton’s original story — and considerably more active.

"[5] USA Today also reviewed the book, writing "In the end, The Andromeda Evolution explodes with an unexpected, gripping, cinematic finale, ready-made.